A new AI tool reveals how tangled DNA knots impact health and disease, offering insights for drug discovery and genetic ...

One of these enzymes, topoisomerase II alpha, is involved in the replication of DNA and cell proliferation, and is highly expressed in rapidly dividing cancer cells.

Researchers have determined the structure of an important smallpox virus enzyme and how it binds to DNA. The enzyme, called a topoisomerase, is an important drug target for coming up with new ways ...

At school, it's often presented as a tidy double helix but scientists are revealing the varied and intricate shapes of DNA ...

DNA topoisomerase 1 is an enzyme present in all organisms, essential for cell proliferation. Its function is based on two catalytic steps: firstly, it cuts and then relinks the DNA, thus relaxing ...

Untangling the heaps of DNA strings during cell division is the job of special enzymes called topoisomerases. How they achieve this feat may be simpler than previously thought, says U of T research.

DNA topoisomerase II (topo II) is an essential nuclear enzyme and is the target for etoposide, which is used in the therapy of childhood acute lymphoblastic leukaemia (ALL).

A new study shows that the DNA repair enzyme Polβ plays a vital role in protecting the developing brain from harmful ...

Researchers have determined the structure of an important smallpox virus enzyme and how it binds to DNA. The enzyme, called a topoisomerase, is an important drug target for coming up with new ways ...