Bacteriophage T4 Dda helicase can displace proteins bound to DNA, including streptavidin bound to biotinylated oligonucleotides.

RNA metabolism regulator DDX3X accumulates at sites of DNA damage in live cells, dependent on PARP1 activity.

Scientists have successfully described a crucial structure involved in DNA replication, placing another piece in the puzzle of how life propagates.

Researchers have identified the mechanism used by the helicase ring to thread around and separate entwined DNA strands in the replication process.

(The NS3 helicase is primarily involved in unwinding the single-stranded RNA of the hepatitis virus, but it can also act on DNA. This suggests that the helicase plays a role in unwinding double ...

Study: Inhibition of the SARS-CoV-2 helicase at single-nucleotide resolution. Image Credit: atdigit/Shutterstock *Important notice: bioRxiv publishes preliminary scientific reports that are not ...

In a paper, the impact of specific DNA lesions is investigated regarding the unwinding activity of NSP13.

The WRN gene is typically responsible for essential tasks like DNA repair, replication, and maintaining telomeres—the protective caps on DNA that shorten with age.

WRN is a helicase required for DNA replication and DNA repair and is a validated target for tumors with microsatellite instability (MSI).

Some strains of herpes simplex virus are resistant to standard treatments, and current alternatives can be problematic. A new drug, a helicase-primase inhibitor, holds promise.

Transcriptomic and protein expression analysis of helicase antigen (HAGE) in triple negative breast cancer (TNBC) as a novel prognostic and predictive biomarker.