How chromatin responds to transcription-blocking DNA lesions is unclear. This study reveals that RNA polymerase II (RNAPII) ...

Shape, size of DNA lesions caused by toxic agents affects repair of DNA Date: June 13, 2017 Source: University of California San Diego Summary: A team of researchers has identified and described ...

A new process, nucleophagy, repairs damaged DNA that is particularly relevant for patients undergoing colorectal cancer treatment.

All damage types do not have the same biological significance. Here arguments are presented supporting the view that lesions in which damage is present on both strands in a local region of the DNA ...

DNA-repair pathways are classified on the basis of the target lesion in the DNA, and the clinical outcome is often similar when components of the same pathway are affected (Figure 1).

Ultraviolet (UV) light damages DNA, producing small lesions. These UV lesions are first detected by a protein complex known as UV-DDB and -- once the lesions have been identified -- the rest of ...

DNA-protein crosslinks (DPCs) are bulky lesions in which unwanted proteins attach to DNA, blocking the process of copying the cell's DNA.

Photo adducts are lesions formed by a light-induced reaction in cellular DNA, which can lead to skin cancers. (The numbers 6-4 refers to the location of the relevant segment of DNA, see ...

A new study shows that the DNA repair enzyme Polβ plays a vital role in protecting the developing brain from harmful ...

In a paper, the impact of specific DNA lesions is investigated regarding the unwinding activity of NSP13.