Cells have to protect the genome, and there are mechanisms in place to repair DNA damage that does arise. But sometimes those mechanisms fail. New research reported in Nature Communications has ...

Bowel cancer cells have the ability to regulate their growth using a genetic on-off switch to maximize their chances of survival, a phenomenon that's been observed for the first time by researchers at ...

Researchers have discovered new regions of the human genome particularly vulnerable to mutations. These altered stretches of ...

The findings may have important implications for diseases linked to mitochondrial dysfunction. A newly identified form of DNA damage inside mitochondria, the small structures that supply energy to our ...

Mitochondrial DNA has long been treated as a workhorse record of cellular history, but new research suggests it also hides a subtle and previously overlooked form of damage. By uncovering this cryptic ...

A previously unknown type of DNA damage in the mitochondria, the tiny power plants inside our cells, could shed light on how ...

While most known types of DNA damage are fixed by our cells’ in-house DNA repair mechanisms, some forms of DNA damage evade repair and can persist for many years, new research shows. This means that ...

Impact of Genomic Alterations on Efficacy of Trastuzumab Deruxtecan Against Human Epidermal Growth Factor Receptor-2–Positive Advanced Gastric Cancer This was a prospective, cross-sectional, ...

Dr. Elizabeth R. Plimack, MD, MS, FASCO, is lead author of a paper in European Urology reporting on an analysis of specimens from the SWOG S1314 trial in localized muscle-invasive bladder cancer that ...

Researchers have developed a novel genome editing technique known as NICER, which results in significantly fewer off-target mutations than CRISPR/Cas9 editing. The technique uses a different type of ...