Two studies show how a small change in FAN1, a DNA repair protein, can speed up HD. The alteration disrupts FAN1’s DNA grip, ...

Cells have to protect the genome, and there are mechanisms in place to repair DNA damage that does arise. But sometimes those mechanisms fail. New research reported in Nature Communications has ...

The team identified a strong correlation between DNA repair mutations in the MSH3 and MSH6 genes, and an overall high volume of mutations. The theory that these 'flip-flop' mutations in DNA repair ...

In a step toward treating mitochondrial diseases, researchers in the Netherlands have successfully edited harmful mutations in mitochondrial DNA using a genetic tool known as a base editor.

An analysis of pre-treatment tumor specimens from 105 patients with localized muscle-invasive bladder cancer found that the presence of a mutation in any one of three genes, all known to be ...

A research group led by the University of Osaka has discovered that the DNA repair enzyme Polβ plays a crucial role in ...

An analysis of pre-treatment tumor specimens from 105 patients with localized muscle-invasive bladder cancer found that the presence of a mutation in any one of three genes, all known to be ...

However, cellular repair of double-strand breaks can lead to unintended DNA mutations, as well as the integration of exogenous DNA to the human genome, which raises safety concerns for clinical ...

A new study shows that the DNA repair enzyme Polβ plays a vital role in protecting the developing brain from harmful ...

Researchers believe that most mutations start as nucleotide mismatches or damage in one of the two strands of the DNA, and if the cell fails to repair them, then the changes are at risk of becoming ...