Two studies show how a small change in FAN1, a DNA repair protein, can speed up HD. The alteration disrupts FAN1’s DNA grip, ...

A new discovery offers hope for Huntington’s disease. This discovery provides hope that a DNA repair process may help slow or stop disease progression.

A research team has successfully identified a novel DNA damage repair pathway in human cells. This study is the first to ...

RNA-binding proteins use a dual binding mechanism involving zinc finger (ZnF) domains and intrinsically disordered regions ...

Researchers in the Adeyemi Lab uncover novel DNA repair factor FLIP that regulates RAD51 and ensures completion of homologous recombination after replication stress.

Although the proteins involved in the FA pathway were discovered some time ago, a mystery remained over how they identified the cross-linked DNA and started the process of DNA repair.

DNA repair proteins act like the body’s editors, constantly finding and reversing damage to our genetic code. Researchers have long struggled to understand how cancer cells hijack one of ...

DNA repair is essential for the maintenance of genomic stability and its failure can lead to human disease. Various DNA repair systems exist, such as base excision repair, nucleotide excision ...

Following a double-strand DNA break, an enzyme called PARP1 helps hold the two strands together —like superglue— and creates a safe zone for other proteins to come repair the damage. We don ...

New research from the Kind Group at the Hubrecht Institute sheds light on how cells repair damaged DNA. For the first time, the team has mapped the activity of repair proteins in individual human ...

Damage to DNA strands resulting in breakage can lead to chromosomal translocation, uncontrolled cellular growth and cancer. These breaks can occur following exposure to agents such as ionizing ...