Holliday junctions act as recognition signals near the ORCs of eukaryotic DNA during replication. Other proteins, such as MLL, WRN, 14-3-3, and DEK also show preferential binding.

CGGBP1 binds to short CGG repeats in gene promoters, recruiting RNA:DNA helicases like DDX41 to ensure proper transcription ...

Origin-recognition complex (ORC) plays an unexpectedly broad role in the regulation of human cell gene expression, according ...

Grant D. Schauer, Michael E. O’Donnell, Quality control mechanisms exclude incorrect polymerases from the eukaryotic replication fork, Proceedings of the National Academy of Sciences of the United ...

In eukaryotes, DNA wraps around histone octamers to form chromatin in the nucleus. The licensing and activation of replication origins are regulated by both the DNA sequence and chromatin features.

DNA repair and replication pathways converge on a common final step in which the continuity of the repaired DNA strand is restored by DNA ligase, an enzyme that converts nicks into phosphodiester ...

Remus D. The role of Mcm2-7 in replication initiation. In The Initiation of DNA Replication in Eukaryotes (2016). Springer. DOI 10.1007/978-3-319-24696-3 Gros J, Kumar C, Lynch G, Yadav T, Whitehouse ...

Untangling a DNA replication mystery may lead to new antimalarial drugs Date: February 2, 2022 Source: John Innes Centre Summary: The function of an enzyme, critical to most forms of life, has ...

Researchers at the Smithsonian and around the world are working to sequence the genomes of every eukaryotic species on Earth in the next 10 years through the Earth BioGenome Project.