DNA repair is essential for the maintenance of genomic stability and its failure can lead to human disease. Various DNA repair systems exist, such as base excision repair, nucleotide excision ...

Recently a human genetic study uncovered about a dozen DNA regions in the genome that harbors "modifiers" for Huntington's disease, which are DNA variants that could hasten or delay the onset of ...

For decades, large stretches of human DNA were dismissed as "junk" and considered to serve no real purpose. In a new study ...

New UB research has found that triggering a cell's DNA damage response could be useful in developing treatments for some disease-causing viruses.

A new AI tool reveals how tangled DNA knots impact health and disease, offering insights for drug discovery and genetic ...

Thousands of previously “invisible” microproteins—tiny chains of fewer than 100 amino acids—can profoundly change human ...

Researchers with McMaster University have discovered that the protein mutated in patients with Huntington disease doesn't repair DNA as intended, impacting the ability of brain cells to heal ...

Researchers have revealed the structural mechanisms of a major DNA repair pathway in human cells. The research, published today as a Reviewed Preprint in eLife, is described by the editors as a ...

University of Zurich researchers have developed Pythia, an AI tool that predicts how cells repair DNA after CRISPR cuts, guiding ultra-precise edits. Tested in human cells, frogs, and mice, the method ...

Inherited dynamic DNA repeat mutations affect over 30 neurological disorders and several of them also found mismatch repair genes that could affect the repeat instability or disease severity.