Researchers revealed that two molecules, PTEN and PIP3, mutually inhibit each other to ensure their exclusive distribution at opposite ends of motile cells. This polarized distribution results in the ...

Malignant astrocytomas are lethal, invasive brain tumors that resist all known treatments, primarily because of their infiltrative growth. Breakdown of the blood brain barrier (BBB), a characteristic ...

Researchers from Sun Yat-Sen Memorial Hospital and affiliated organizations published data from a study that aimed to explore the mechanism of prostate cancer (PCa) metastasis to discover an intrinsic ...

Mutually exclusive distribution of PIP3 and PTEN on the plasma membrane of a migrating cell. (left) A Dictyostelium discoideum cell migrating rightward. The cell expresses PIP3-binding protein tagged ...