Homologous recombination deficiency (HRD) is a well-described phenotype of some prostate cancers; however, current biomarkers for HRD are imperfect and rely on detection of single gene alterations in ...

PURPOSEThe prevalence of homologous recombination repair gene mutations (HRRm) in patients with metastatic castration-resistant prostate cancer (mCRPC) in Latin America and the Caribbean (LAC) is ...

Next-generation PARP inhibitor demonstrates clinical benefit in patients with homologous recombination repair-deficient breast cancer ...

Homologous recombination repair mutations have been identified in up to 25% of patients with metastatic disease. This study shows that early intervention with a PARP inhibitor may improve outcomes.

Fizazi K, Azad A, Matsubara N. Final overall survival with talazoparib + enzalutamide as first-line treatment in patients with homologous recombination repair-deficient metastatic castration ...

Tokyo, Japan – Researchers from Tokyo Metropolitan University have been studying DNA repair by homologous recombination, where the RecA protein repairs breaks in double-stranded DNA by ...

The cryoEM structure of a RAD51 displacement loop reveals the molecular mechanism of the strand-exchange reaction at the centre of eukaryotic homologous recombination.

Oncogenic variants in homologous recombination repair genes were detectable in newly diagnosed non–metastatic tumors.

NEW YORK – GSK will roll out its anti-PD-1 therapy Jemperli (dostarlimab) for certain endometrial cancer patients and its PARP inhibitor Zejula (niraparib) for ovarian cancer patients in India.

If homologous recombination can be blocked, the team reasoned, cells would need to repair themselves in other ways, which would lead to them dying when the immune system will notice.