Unexpected slowdowns or spikes in this signal were often interpreted as knots in DNA. But now, a new study published Aug. 12 ...

How chromatin responds to transcription-blocking DNA lesions is unclear. This study reveals that RNA polymerase II (RNAPII) ...

A cell protein previously believed only to provide a scaffolding for DNA has also been shown to directly influence DNA transcription into RNA – the first step of the process by which an organism ...

What happens on the atomic scale when DNA transcription is paused has been unveiled for the first time.

Cancer represents the most extensively studied disease category involving transcription factor dysregulation, with multiple TFs driving distinct oncogenic mechanisms. Hypoxia-inducible factors (HIFs), ...

DNA often experiences torsional stress inside living cells ... occurs naturally inside cells and what role it might play in ...

Hypoxia-inducible factors (HIFs), ETS-1, MYC, and β-catenin act as master regulators that constitutively activate oncogenic ...