Shapiro served as Deputy Assistant Secretary of Defense for the Middle East until January—charged with, among other things, considering scenarios in which tensions between Israel and Iran escalated into all-out war and preparing U.

Iranian officials have warned that U.S. participation in an attack on its facilities will imperil any chance of the nuclear disarmament deal the president insists he is still interested in pursuing.

Iran fired a new wave of missile attacks on Israel early Monday, triggering air raid sirens across the country as emergency services reported at least five killed and dozens more wounded in the fourth day of a conflict between the regional foes that showed no sign of slowing.

What we are seeing now is the rhetoric — and the wisdom — of “America First” become reality in the skies over Tehran.

"Israel is being assisted this way or that way by some Iranians," ex-Israeli National Security chief Giora Eiland told Newsweek.

Only the U.S. military has the 30,000-pound bomb capable of reaching the facility and the bomber that can carry it.

Israeli PM Netanyahu compared Iran's nuclear program to cancer, vowing it must be "cut out." He said Israel will destroy Iran's nuclear, missile, and terror infrastructure, with US support. He also hinted the Iranian regime could collapse under pressure,

Israeli Prime Minister Benjamin Netanyahu spoke with ABC News' Jonathan Karl about Israel's attack on Iran's nuclear program and Iran's retaliation against his country.