Regulation of transcription in eukaryotes is a result of the combined effects of structural properties (how DNA is "packaged") and the interactions of proteins called transcription factors.

Learn about gene transcription, the first step in gene expression. Discover the process, regulation, and significance of how DNA is copied into RNA.

This article describes the three types of RNA polymerase (RNAP), the enzyme responsible for transcription in eukaryotic cells.

The potential for catastrophic consequence underpins the importance of selecting the correct decision between DNA repair and transcription.

The regulation of mRNA transcription plays a key role in relaying signals from the environment and during development into the gene expression program of a cell. During transcription initiation, a ...

How chromatin responds to transcription-blocking DNA lesions is unclear. This study reveals that RNA polymerase II (RNAPII) ...

High noise is often thought to be detrimental for cells, yet genes in eukaryotes are quite noisy. "So far, we don't really know why this whole transcription machinery has evolved that way.

CGGBP1 binds to short CGG repeats in gene promoters, recruiting RNA:DNA helicases like DDX41 to ensure proper transcription ...

A detailed picture of what happens when DNA transcription is paused early in the process has been obtained by structural biologists at RIKEN. This could inform the development of new therapies.