A double-strand break (DSB) is a type of DNA damage where both strands of the DNA helix are cut or broken at the same location, causing a complete discontinuity in the DNA molecule.

DNA double-strand breaks (DSBs) represent one of the most deleterious forms of genetic damage, arising naturally during cellular replication or as a result of exposure to ionising radiation. The ...

The platform enables direct, unbiased genome-wide identification and quantification of the exact position of double strand DNA breaks in edited cells.

As a postdoc, Komor found a way to achieve gene-editing with higher efficiencies and a lower incidence of indels by avoiding double-stranded breaks.

The cryoEM structure of a RAD51 displacement loop reveals the molecular mechanism of the strand-exchange reaction at the centre of eukaryotic homologous recombination.

A research team has successfully identified a novel DNA damage repair pathway in human cells. This study is the first to ...

Beam Therapeutics' base editing technology shows early promise in sickle cell and AATD, but commercial success is years away ...

Even the much-publicized CRISPR-Cas9 system has limitations: These molecular scissors create double-stranded DNA breaks, which the cell must stitch back together with error-prone repair processes, ...

Prime editing is an advanced gene editing technology that enables precise DNA corrections without introducing double-stranded breaks, significantly reducing off-target effects. This innovation ...