Baseball's two best teams will meet this weekend not in Los Angeles or New York or Philadelphia. The AL-best Detroit Tigers will host the NL-best Chicago Cubs for a three-game interleague series at Comerica Park.

The Chicago Cubs (39-24) and Detroit Tigers (42-23) play the second game of their 3-game series Saturday. First pitch from Comerica Park is set for 1:10 p.m. ET (MLB Network). Let's analyze BetMGM Sportsbook's MLB odds around the Cubs vs. Tigers odds and make our expert MLB picks and predictions for the best bets.

The squads are starting a three-game weekend series with each hoping to extend its division lead. They also hold the two best records in MLB entering the day with the Tigers being the first team to 40 wins and the Cubs having the fewest losses among 39-win teams.