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Optimised genome editing for precise DNA insertion and substitution using Prime Editors in zebrafish
This study presents a valuable comparison of the efficiency and precision of two prime editing methods to introduce single-nucleotide variants and longer exogenous DNA sequences into the zebrafish ...
The efficiencies with which activated B lymphocytes proliferate and develop into antibody (Ab)- secreting plasma cells are critical determinants of adaptive humoral immunity and central to sustaining ...
Figure 3. NSP13 helicase activity is required for suppressing YAP activity. (A) Conserved amino acid sequences of NSP13 among coronaviruses. (B) SARS-CoV-2 NSP13 mutant plasmids were constructed to ...
In this episode, we hear about parasites as molecular matchmakers, drug combinations and cancer treatment, chemical defences in poison frogs, the impact of education on brain structure, and what ...
Figure 1. The timing of polarization at the 8-cell stage is asynchronous. A) Schematic representing mouse pre-implantation development and live imaging of apical-basal polarization through the 8-cell ...
Revised: This Reviewed Preprint has been revised by the authors in response to the previous round of peer review; the eLife assessment and the public reviews have been updated where necessary by the ...
Immunology and Inflammation Xcr1 + type 1 conventional dendritic cells are essential mediators for atherosclerosis progression ...
Altmetric provides a collated score for online attention across various platforms and media. See more details Flat clathrin lattices accumulate in cells depleted of CCDC32. (A-B) Representative PREM ...
The study presents valuable theoretical insights by attempting to classify pattern-forming gene subnetworks and exploring their potential mechanisms. However, the results are incomplete, as they rely ...
Figure 1. Pipeline detailing the workflow of maRQup a, A schematic of the in-vivo experimental setup used to evaluate the efficacy of CAR-T cell immunotherapy experiments. NALM-6 leukemia cells ...
This important study reports an advancement in the diagnosis of Animal African Trypanosomosis (AAT), which adapts a CRISPR-based diagnostic tool (SHERLOCK4AAT) to detect different trypanosome species ...
eLife Assessment By taking advantage of noise in gene expression, this important study introduces a new approach for detecting directed causal interactions between two genes without perturbing either.
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