Spatial metabolomics is transforming our understanding of microbial systems by uncovering the localized molecular dynamics ...

The well-studied NF-κB signaling system is a key mediator of the inflammatory response. Large-scale sequencing studies in ...

Macrophages not only clean the wound early for repair, but are also critically involved in all subsequent phases of proliferation and regeneration (Mirza et al, 2009; Shook et al, 2016).They ...

We demonstrate that TP53 deficiency in AML cells confers resistance to CAR T-cell therapy by inducing CAR T-cell dysfunction. We propose a model in which difficult-to-kill TP53-mutant AML cells ...

Paraneoplastic syndrome represents a diverse array of clinical manifestations occurring in multiple organs of cancer patients, which are not directly attributable to tumor burden or invasion (Kannoth, ...

DarT is present in many bacteria and, in some, an orthologous system, DarT1, is also present, catalysing ADP-ribosylation of guanosine bases in ssDNA (Cihlova et al, 2024; Schuller et al, 2023).In ...

The effect of the DNMT3A R882 H mutation in a pre-leukaemic setting is not well understood. The murine homologue of the R882H mutation is R878H, and Dnmt3a R878H mouse models (Dai et al, 2017; Liao et ...

In the 1950s, Harold Flor first proposed a framework for host‐pathogen interactions termed the gene‐for‐gene model, in which matching pairs of genes from a host and a pathogen determine the outcome of ...

Recently, we were able to show that both SARS-CoV-2 infection and mRNA vaccination prime human monocyte-derived macrophages for potent secretion of pro-inflammatory cytokines following restimulation ...

In this context, the process of autophagy can be considered as a bona fide health‐modifying agent (Choi et al, 2013; Mizushima & Levine, 2020).Indeed, a large body of evidence from the literature ...

Colorectal cancer stands as the second leading cause of cancer-related mortality worldwide and ranks third in global cancer diagnoses. Despite the efficacy of surgical resection and adjuvant ...

Polyglucosans are glycogen molecules with overlong chains, which are hyperphosphorylated in the neurodegenerative Lafora disease (LD). Brain polyglucosan bodies (PBs) cause fatal neurodegenerative ...