Bispecific T cell engagers (TcEs) that are able to simultaneously bind to epitopes on cancer cells and T cells are a versatile, highly potent, and economical immunotherapeutic tool ().TcEs are ...

Sorting cells with target metabolic functions from a mutant pool exhibiting substantial genetic diversity is often the rate-limiting step in synthetic biology. Here, we developed a label-free, ...

Room-temperature superconductors could revolutionize modern technology by enabling lossless power transmission, powerful magnets, advanced medical imaging (MRI), and quantum computing.

In eukaryotes, genomic DNA is packaged into chromatin, which is the substrate for transcription, DNA replication, repair, and recombination. Within chromatin, nucleosomes contain two copies of each of ...

Pigmentation plays a vital role in the survival of organisms, supporting functions such as camouflage, communication, and mate attraction. In vertebrates, these functions are mediated by specialized ...

Cotyledon greening is a crucial process for seedlings to survive the dark-to-light transition during their soil emergence. While the complex strategies employed by etiolated seedlings to ensure ...

Developing oral biologics has long been a holy grail of protein engineering. Traditional antibodies are large and unstable in the presence of gastrointestinal proteases. Here, we present a strategy to ...

The origin of evolutionary novelties is often underpinned by a complex set of changes. The genetic underpinnings comprise, for instance, gene or genome duplication, mutations, deletions, and ...

Measures of general cognitive ability (GCA) are highly stable from adolescence onward, particularly at the level of genetic influences. In contrast, measurement of GCA in early life (before 3 y old) ...

Astrocytes have a primary cell body (soma) with numerous branching processes that envelope nearby synapses ().This three-part structure is known as the tripartite synapse ().A single astrocyte can ...

These questions also matter for fisheries and a sustainable pet trade. Without knowing which populations seed the most babies into the next generation, fishermen can’t know where is safe to cast nets ...

Physical exercise is known to reduce depression, but the underlying brain mechanisms remain unclear. Based on a chronic restraint stress model in mice, we showed that 4-wk treadmill exercise ...