Objective Over half of patients with IBS have either diarrhoea (IBS-D) or a mixed stool pattern (IBS-M). The relative efficacy of licenced pharmacological therapies is unclear in the absence of ...

Background and aims: The success of Helicobacter pylori eradication regimens depends on gastric pH, inflammation, and mucus thickness. Our aim was to investigate the effects of acid secretion, ...

Peroxisome proliferator-activated receptor gamma (PPARγ) is a nuclear receptor that regulates intestinal inflammation. PPARγ is highly expressed in the colon and can be activated by various dietary ...

Correspondence to Dr Silvio Danese, Gastroenterology and Gastrointestinal Endoscopy Unit, IRCCS San Raffaele Scientific Institute, Vita-Salute San Raffaele University, Milano, Lombardia, Italy; ...

1 Department of Internal Medicine, National Nagasaki Medical Center, Omura, Nagasaki, Japan 2 Second Department of Internal Medicine, Nagasaki University School of Medicine, Sakamoto, Nagasaki, Japan ...

Non-alcoholic fatty liver disease (NAFLD) has rapidly become the most common chronic liver disease globally and is currently estimated to affect up to 38% of the global adult population. NAFLD is a ...

Correspondence to Dr Johann von Felden, Department of Internal Medicine, Universitätsklinikum Hamburg-Eppendorf, Hamburg, Germany; j.von-felden{at}uke.de; Dr Augusto Villanueva, Liver Cancer Program, ...

Objective Stroke is a leading cause of death and disability worldwide. Neuroprotective approaches have failed in clinical trials, thus warranting therapeutic innovations with alternative targets. The ...

The Lyon Consensus provides conclusive criteria for and against the diagnosis of gastro-oesophageal reflux disease (GERD), and adjunctive metrics that consolidate or refute GERD diagnosis when primary ...

Objective To evaluate the potential for diagnosing colorectal cancer (CRC) from faecal metagenomes. Design We performed metagenome-wide association studies on faecal samples from 74 patients with CRC ...

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1 Department of Gastroenterology and Hepatology, University Medical Center Utrecht, Utrecht, The Netherlands 2 Department of Medical Diagnostic Sciences and Special Therapies, Surgical Pathology and ...