Gut

Rise of prediagnostic molecular profiling in inflammatory bowel disease—can we close the door before the horse has bolted?

Inflammatory bowel disease (IBD) is typically diagnosed after the onset of symptoms in the context of established, characteristic patterns of intestinal inflammation. However, there is now substantial ...
gut.bmj

NSUN6 deficiency drives immune suppression in pancreatic cancer via the KDM5A-CCL2-macrophage axis

Background RNA 5-methylcytosine (m 5 C) has emerged as a critical epigenetic regulator in cancer biology, yet its role in the tumour immune microenvironment (TME) remains incompletely understood.
gut.bmj

Alterations of gut microbiome in autoimmune hepatitis

Objective The significance of the liver-microbiome axis has been increasingly recognised as a major modulator of autoimmunity. The aim of this study was to take advantage of a large well-defined ...
gut.bmj

Endoscopic submucosal dissection for early gastric cancer: a large-scale feasibility study

Second Department of Internal Medicine, Nagasaki University School of Medicine, Nagasaki, Japan Dr H Isomoto, Second Department of Internal Medicine, Nagasaki University School of Medicine, 1-7-1 ...
gut.bmj

Prospective comparison of faecal incontinence grading systems

Background Existing scales for assessing faecal incontinence have not been validated against clinical assessment, or with regard to reproducibility. They also fail to take into account faecal urgency, ...
gut.bmj

Non-invasive risk-based surveillance of hepatocellular carcinoma in patients with metabolic dysfunction-associated steatotic liver disease

15 Department of Gastroenterology and Hepatology, Singapore General Hospital, Singapore Background Metabolic dysfunction-associated steatotic liver disease (MASLD) affects over 30% of the general ...
gut.bmj

Hypothesis-generating evaluation of multi-armoured oncolytic HSV-1 (VG161) in intrahepatic cholangiocarcinoma: pooled insights from multicentre studies

2 Zhejiang Provincial Key Laboratory of Pancreatic Disease, Hangzhou, China Background Intrahepatic cholangiocarcinoma (ICC) is a highly aggressive malignancy with limited treatment options and poor ...
gut.bmj

Colonoscopic full-thickness resection using an over-the-scope device: a prospective multicentre study in various indications

Objective Endoscopic full-thickness resection (EFTR) is a novel treatment of colorectal lesions not amenable to conventional endoscopic resection. The aim of this prospective multicentre study was to ...
gut.bmj

Anti-HBV DNA vaccination does not prevent relapse after discontinuation of analogues in the treatment of chronic hepatitis B: a randomised trial—ANRS HB02 VAC-ADN

Objective The antiviral efficacy of nucleos(t)ide analogues whose main limitation is relapse after discontinuation requires long-term therapy. To overcome the risk of relapse and virological ...
gut.bmj

IDDF2025-ABS-0356 Catenibacterium mitsuokai promotes hepatocellular carcinogenesis by binding to hepatocyte and generating quinolinic acid

2 Institute of Digestive Disease and the Department of Medicine and Therapeutics, State Key Laboratory of Digestive Disease, Li Ka Shing Institute of Health Sciences, The Chinese University of Hong ...
gut.bmj

Setting a vision for British Society of Gastroenterology guidelines: embracing innovation while preserving methodological excellence and clinical utility

Correspondence to Dr Matthew Kurien, Division of Clinical Medicine, School of Medicine & Population Health, The University of Sheffield Faculty of Medicine Dentistry and Health, Sheffield, South ...
gut.bmj

IDDF2025-ABS-0191 Development of 3D multi-scale vascularized sinusoid-like model for liver tissue repair bridging for liver transplant

Background Liver failure is the most critical outcome of end-stage liver diseases, with a 28-day mortality rate in the acute phase ranging from 25% to 84% due to a narrow therapeutic window. Liver ...