Rapid pathogen detection is crucial for effective disease management, particularly in bloodstream infections. Current molecular diagnostics often require nucleic acid preamplification, adding time and ...

High-resistant starch (RS)/low-glutelin sbeIIb/Lgc1 lines were generated by CRISPR-Cas9-induced site-specific mutations in SBEIIb in an elite low-glutelin japonica rice cultivar ().According to this ...

We demonstrate that substitutionally inert octahedral metal complexes, such as the iridium(III) carbene complex (1a), provide a useful source of potent inhibitors for unexplored oncogenic protein ...

Contributed by Ian J. Bateman; received April 20, 2024; accepted October 3, 2024; reviewed by Roy Brouwer, Catherine L. Kling, and Marije Schaafsma This contribution is part of the special series of ...

In eukaryotes, genomic DNA is packaged into chromatin, which is the substrate for transcription, DNA replication, repair, and recombination. Within chromatin, nucleosomes contain two copies of each of ...

Cotyledon greening is a crucial process for seedlings to survive the dark-to-light transition during their soil emergence. While the complex strategies employed by etiolated seedlings to ensure ...

The origin of evolutionary novelties is often underpinned by a complex set of changes. The genetic underpinnings comprise, for instance, gene or genome duplication, mutations, deletions, and ...

Despite these successes, polyhydride synthesis remains challenging. For instance, it took nearly a decade to experimentally realize CaH 6 (12, 13) after its theoretical prediction ().A major hurdle is ...

Bispecific T cell engagers (TcEs) are immunotherapeutic drugs that trigger the destruction of cancer cells by linking T cells to cancer cells through specific surface molecules (antigens). We designed ...

Sorting cells with target metabolic functions from a mutant pool exhibiting substantial genetic diversity is often the rate-limiting step in synthetic biology. Here, we developed a label-free, ...

Developing oral biologics has long been a holy grail of protein engineering. Traditional antibodies are large and unstable in the presence of gastrointestinal proteases. Here, we present a strategy to ...

Pigmentation plays a vital role in the survival of organisms, supporting functions such as camouflage, communication, and mate attraction. In vertebrates, these functions are mediated by specialized ...