Iran’s supreme leader has denounced a proposal by the United States aimed at curbing Tehran’s nuclear efforts and demanded that his country retains national independence amid reports of Washington offering to become involved in Tehran’s nuclear program.

Iran's Supreme Leader Ayatollah Ali Khamenei said on Wednesday that abandoning uranium enrichment was "100%" against the country's interests, rejecting a central U.S. demand in talks to resolve a decades-long dispute over Tehran's nuclear ambitions.